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Talking testosterone
deficiency (TD)

Talking Testosterone Deficiency

Signs and symptoms

Signs and symptoms

Low mood,
depression and
weight gain are just
some of the symptoms
men may experience in
addition to low libido,
as a result of TD.

Testosterone has an important influence on many homeostatic processes in the body, affecting overall male health

The disruption of this homeostasis is reflected in the wide-ranging signs and symptoms of TD.

Signs and symptoms diagram
Symptomatic TD affects 2.1% of men aged 40–79 and is associated with poor cardiac health, metabolic dysfunction and early mortality6,9

Common symptoms of testosterone deficiency

Watch Professor Abraham Morgentaler of the Harvard Medical
School in Boston discuss Common Symptoms of Testosterone

Professor Abraham Morgentaler


  1. Kirby M, Hackett G, Ramachandran S. Testosterone and the Heart. Eur Cardiol Rev. 2019;14(2):103–110.
  2. Zarotsky V, Huang M-Y, Carman W, et al. Systematic literature review of the risk factors, comorbidities, and consequences of hypogonadism in men. Andrology. 2014;2(6):819–834.
  3. Sharma R, Oni OA, Gupta K, et al. Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. Eur Heart J. 2015;36(40):2706–2715.
  4. Zeller T, Schnabel RB, Appelbaum S, et al. Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women – results from the FINRISK study. Eur J Prev Cardiol. 2018;25(11):1133–1139.
  5. Araujo AB, Dixon JM, Suarez EA, et al. Clinical review: Endogenous testosterone and mortality in men: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011;96(10):3007–3019.
  6. Traish AM. Adverse health effects of testosterone deficiency (TD) in men. Steroids. 2014;88:106–116.
  7. Khera M, Adaikan G, Buvat J, et al. Diagnosis and Treatment of Testosterone Deficiency: Recommendations From the Fourth International Consultation for Sexual Medicine (ICSM 2015). J Sex Med. 2016;13(12):1787–1804.
  8. Lunenfeld B, Mskhalaya G, Zitzmann M, et al. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men. Aging Male. 2015;18(1):5–15.
  9. Wu FCW, Tajar A, Beynon JM, et al. Identification of Late-Onset Hypogonadism in Middle-Aged and Elderly Men. N Engl J Med. 2010;363(2):123–135.

TES/2020/009. April 2021.

Adverse event reporting

Adverse events should be reported. Reporting forms and information can be found at or search for MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to Besins Healthcare (UK) Ltd Drug Safety on 0203 862 0920 or Email: